In a life-changing decision, Bert Large abandons his plumbing business to open his own restaurant. The opening of Large's restaurant is far from a success, when Doc Martin, who has a phobia about blood, finds a spot of blood on his plate. To make matters worse for Bert, the following day, the doctor's office is inundated with patients with symptoms of food poisoning, and all claiming to have eaten at his restaurant.
The Oakwoods, a family of city slickers seeking a new life by the sea, set out to disrupt the tranquility of Portwenn. They manage to gatecrash an intimate dinner Louisa has prepared for her and Martin. With their romantic dinner plans ruined, the disgruntled doctor decides to make a hasty exit leaving Louisa to deal with the neighbors from hell. A car vandal is on the loose in Portwenn. Cars belonging to the doctor, his Aunt Joan and Bert Large have all been damaged. The doctor reports the vandalism to PC Penhale, but he seems strangely reluctant to investigate. He has to confess he is suffering from agoraphobia and can't leave the police station.
Portwenn looks set to become a hotbed of passion. Louisa Glasson is furious to discover she has a rival for Doc Martin's affections: glamorous divorcee and hotel owner, Carrie Wilson. Can Louisa contain her jealously and claim Martin as her man before Carrie's flirty tactics take effect? On his way to PC Penhale's birthday party, Martin accidentally reverses his car into Carrie's dog, killing him. Carrie is distraught by the death of her dog and slaps Martin across the face when he hands her the dog, and tries to apologize.
The Holly Bears A Prickle
It has taken three seasons, but Doc Martin and Louisa are finally going on their first date. However, in typical fashion, the clumsy doctor manages to ruin the moment with an inappropriate remark, and Louisa ends their affair, leaving Martin shell shocked. The break-up hits Martin harder than he anticipated. But there's one more chance to redeem himself when he gets an urgent call for help from Louisa to treat her friend Holly. As Martin leaves Louisa's house, he realizes he could lose her forever. He pauses on the doorstep and asks her to marry him.
Nowt So Queer
Portwenn is buzzing with the news of the engagement of Dr Martin Ellingham and Headmistress Louisa Glasson. Mushrooms are the cause of an outbreak of aspergillosis in the village. Bert Large, postman Dave and restaurant chef Mick Mabley are among the victims. Bert Large's ill health is not his only problem. His restaurant is in financial trouble. Son Al decides it is time to take action to save the business.
Happily Ever After
Martin manages to offend the local vicar who is due to conduct Martin and Louisa's wedding ceremony by suggesting he has a drinking problem. In a struggle over a bottle of whisky, the vicar stumbles and fractures his pelvis. As the ambulance takes the vicar to hospital, Martin is left with the dilemma of finding a replacement vicar with just three hours to go to the wedding. With less than an hour to go to the ceremony, pregnant bridesmaid Isobel goes into labor. Martin is summoned by Louisa, and on a windswept hill top above Portwenn he delivers a healthy baby boy. Now it's a race against time for Martin and Louisa to get to the church on time....
Better The Devil
Uneasy Lies The Head
Perish Together As Fools
Driving Mr. McLynn
Martin meets Portwenn's new midwife, Molly, who will be looking after Louisa. Martin is dismissive of her profession, and the two of them do not hit it off. Martin finds that cognitive behavioral exercises are a great help with his blood phobia and he is able to take blood from P.C. Penhale without reacting. Martin visits Aunt Joan at her farm, and breaks the news that he is intending to become a surgeon in London again. She is supportive, but urges him to tell Louisa. Martin and Molly have their final stand-off when Louisa develops a temperature which Molly tries to sooth with herbal remedies. Martin is furious when he discovers this - believing Molly's homespun ideas are seriously endangering Louisa's health. Edith has big news for Martin that Louisa overhears - Robert is going to offer him the prestigious surgeon's job in London.
Do Not Disturb
To solve her farm's money problems, Aunt Joan starts a small bed-and-breakfast business. Her first guest, unexpectedly, is another local farmer, Ted, who has also got into financial difficulties. Initially they're a good match, but Joan soon finds that Ted is far from the perfect guest. Pauline's suspicions are confirmed when she steams open a confidential letter addressed to Martin and discovers his contract offer for the London job. Suddenly insecure about her own future, she confronts Martin, who offers her no reassurances other than to write her a reference. Martin deals with the victim of an accident without hesitation, proving to both himself and Edith that his blood phobia is completely cured, and he is now fully able to be a surgeon in London again.
The Wrong Goodbye
Martin and Pauline are surprised by the number of patients coming to see him on the last day before his Surgery closes and he moves to London. Taxi driver Tommy delivers a patient to the Surgery, but complains of migraine headaches himself. Martin checks him for any serious brain conditions, and tells him to make an appointment with the new doctor if the headaches continue. Martin is driving out of Portwenn with the moving men when he sees Tasha fall from the Harbour Day stage. With a little bit of help from a guilty Bert and Al, he is able to diagnose Tasha's medical condition, and is shocked to learn that she is married to taxi driver Tommy, and that he is driving Louisa to her hospital appointment. Louisa's life is in danger. Martin rushes after Louisa, finding her safe at the scene of a road accident caused by Tommy. Martin and Louisa help Tommy to a nearby inn where his medical condition can be treated; but due to her exertions, Louisa goes into premature labor.
Preserve The Romance
Dr. Martin Ellingham (Martin Clunes) is struggling to come to terms with fatherhood. The baby boy born to him and his estranged partner, Louisa Glasson (Caroline Catz), is about to change their lives dramatically. Doc Martin had planned to resume his high-flying career as a consultant in London. He had packed his bags and moved out of the surgery to make way for the new GP, Dr. Di Dibbs (Joanna Scanlan). However Dr. Ellingham begins to have serious doubts about the competency of the new GP after she misdiagnoses a patient, and dishes out prescriptions for totally inappropriate drugs. Dr. Dibbs realizes she has to go, and Dr. Ellingham agrees to resume duties at the surgery until a replacement GP can be found. With all the upheaval the doc is unprepared for a devastating personal blow with the death of Aunt Joan.
Dry Your Tears
With the departure of Dr. Dibbs, Dr. Ellingham moves back into his old surgery, agreeing to stay for a couple of months until a replacement can be appointed. Determined to get to grips with fatherhood, he asks Louisa to move into his house so he can help to raise their child. He even suggests that Louisa and still un-named "baby" could move to London with him. Aunt Joan's sister Ruth Ellingham (Dame Eileen Atkins) attends the funeral and demonstrates the same cantankerous character as her nephew. She has no more intention of staying in Portwenn than Martin does, but Joan has left her the house and farm.
Born with a Shotgun
Sleepless nights are taking their toll on Martin and Louisa. Tempers are frayed as they try to find ways to comfort their constantly wailing baby. Aunt Ruth has problems of her own: She is dealing with an intruder on the farm who has stolen the hub caps from her car. The thief is identified as Michael Dunwich (Andrew Lee Potts), who lives with his mother Shirley (Miriam Margolyes) on a neighboring farm. Shirley makes an appointment with Martin to discuss the crippling stomach pains she has been suffering. When her son is out of the room, Shirley tells the doc she thinks her son is trying to poison her. The results of the tests on Shirley Dunwich show a heavy concentration of arsenic in her system. The doc immediately calls P.C. Penhale (John Marquez) suspecting that Shirley is actually being poisoned by her son!
Mother Knows Best
It's Portwenn Fun Day and the village is buzzing with excitement about this major fund raising event. P.C. Penhale is in his element rallying the runners and whipping up support. The event sparks culinary rivalry between Bert Large (Ian McNeice) who runs Large's restaurant with son Al (Joe Absolom) and Mark (Tim Goodman Hill), the landlord of the Crab and Lobster pub. Louisa's mum Eleanor (Louise Jameson) arrives in Portwenn unexpectedly and Louisa is far from happy about her arrival. She hasn't seen her mother for years, so why the sudden interest?
P.C. Joe Penhale (John Marquez) has an unexpected visitor - his ex-wife Maggie (Julie Graham). She appears to have completely forgotten that they split up a couple of years ago. When he tries to tell her they are no longer married she accuses him of over-reacting, and wants to know why he packed his bags and left her. Joe struggles with a mixture of distress and elation at seeing Maggie again. He has thought about her every day since they parted. He realizes she is clearly not well, and tries discreetly to ask Dr. Ellingham about her symptoms without telling him that he is talking about his ex-wife. Meanwhile, Martin and Louisa's baby still doesn't have a name, and P. C. Penhale warns them that time is running out. If they don't register a name for the baby soon the State will step in and name the baby. After protracted discussions the couple finally reaches an agreement.
Don't Let Go
P.C. Joe Penhale is desperate to keep Maggie and show her he's changed; that he's the macho husband she wants. But Maggie plans to return to Bude. Penhale resorts to desperate measures to convince her to stay, including surreptitiously paying people to be nasty to her so he can step in and assert his authority, and show her he can be tough. Aunt Ruth uncovers a chest of family heirlooms when she clears out a barn at the farm, including photos as Martin as a six-year-old schoolboy. The photos bring back poignant memories of an unhappy childhood for Martin and it prompts him to think of registering their son for boarding school. But Louisa is horrified at the thought of sending him miles away to school. Tension is mounting between Louisa and Martin. They can't seem to agree on anything. The final straw for Louisa comes when she discovers Martin has set a date for their baby's christening without even consulting her. Louisa decides she has had enough. She packs a bag, and takes the baby back home to her mum.
Cats and Sharks
Bert Large's restaurant business is in financial trouble. He can't even afford the food and drink for a charity event to raise money for Florence Dingle's (Anne Reid) cat sanctuary. Mrs. Dingle is distraught. She desperately needs the money to continue to look after the cats and kittens in her care. Eleanor comes to Bert's rescue with a plan to boost business at the restaurant, suggesting they have a Spanish theme night to attract customers. She rolls up her sleeves and begins preparing for the Spanish feast. But she begins to feel very ill and Louisa insists she must see the doc. Morwenna calls an ambulance, but the Doc decides there is no alternative: he must operate now on Eleanor in his surgery or she could die. Dr. Martin Ellingham is planning to leave Portwenn in a week's time to resume his career as a surgeon, leaving Louisa and the baby in the village. They have the christening to organize before he leaves. But as usual the doc shows little interest in the event, leaving it all to Louisa.
Mrs. Tishell's (Selina Cadell) long-standing crush on Dr. Martin Ellingham takes a dramatic turn in this final episode in the series. Fuelled by a cocktail of drugs Mrs. Tishell can no longer hide her unrequited love for the doc, and decides she must take drastic action. Her husband Clive (Malcolm Storry) arrives back unexpectedly from his work on the oil rigs announcing his intention to retire so they can spend more time together. It's now or never for Mrs. Tishell to make her romantic notions of a relationship with the doc come true. With Doc and Louisa's baby in her care, she boards a bus out of the village leaving an enigmatic message for Dr. Ellingham to meet them at the castle.
Sickness and Health
Portwenn is buzzing with arrangements for the wedding of the Doc and Louisa. Will they finally tie the knot, or will the villagers have to put the confetti back in the box again?
Guess Who's Coming to Dinner?
Martin and Louisa host a disastrous dinner party, the new nanny walks out, and Morwenna advertises for a lodger.
The Tameness of a Wolf
Ruth is invited on Radio Portwenn and attracts an unwanted mystery admirer. Doc and Louisa find a replacement nanny. And Louisa is Bert's least favorite person when one of her pupils pens a damning review of his restaurant in the school magazine.
Nobody Likes Me
Martin is coerced into taking James to playgroup, while Ruth is having problems with her new neighbor.
The Practice Around The Corner
Mrs. Tishell returns to the village. Martin has to work out what is wrong with beachcomber Lorna. Al and Morwenna each have an internet dating disaster, and romance is blossoming for Bert.
Martin's mother returns to Portwenn with some interesting news. Penhale spreads pandemonium throughout the village at the drop of the word "asbestos" and Bert has a question for Jennifer.